Candida prosthetic valve endocarditis (PVE) is a rare entity. However, its incidence is expected to increase along with increasing incidence of nosocomial candida infection. A valve replacement combined with antifungal chemotherapy has been the standard treatment. However, successful treatment with the long-term administration of oral fluconazole has been reported. Herein, a case of bioprosthetic valve endocarditis due to candida parapsilosis, which recurred after a re-do operation, and treated with long-term antifungal chemotherapy, is reported.