Journal List > Korean Circ J > v.34(10) > 1074721

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Moon, Lee, Chang, Yoo, Jeon, Youn, Chung, Lee, Kim, Seung, Kim, and Hong: Oral Everolimus Reduces Adventitial Cell Activation and Neointima Formation in Balloon-Injured Rat Carotid Artery
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Korean Circulation Journal

Korean Circulation Journal 2004; 34(10): 983-991.

Published online: 31 October 2004

DOI: https://doi.org/10.4070/kcj.2004.34.10.983

Oral Everolimus Reduces Adventitial Cell Activation and Neointima Formation in Balloon-Injured Rat Carotid Artery

Keon Woong Moon, Jong Min Lee, Kiyuk Chang, Ki Dong Yoo, Doo Soo Jeon, Ho Joong Youn, Wook Sung Chung, Man Young Lee, Jong Jin Kim, Ki Bae Seung, Chul Min Kim, Soon Jo Hong

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

yookd@dreamwiz.com

Copyright © 2004 The Korean Society of Circulation

Abstract

BACKGROUND AND OBJECTIVES: Previous studies suggest that phenotypic conversion, proliferation and migration of adventitial fibroblasts after balloon injury have an important role in neointimal formation and vascular remodeling. The present study evaluated whether orally administered everolimus (a macrolide of the same family as sirolimus) reduces adventitial cell activation and neointimal formation in balloon-injured rat carotid arteries.
MATERIALS AND METHODS: Oral everolimus (1.25 mg/kg/day), or a matching placebo, was administered daily to 30 rats by gavage, starting 3 days before balloon injury. The treatment effects were assessed 3, 7 and 14 days after injury.
RESULTS: The oral everolimus group showed a significant reduction in adventitial cell proliferation at 3 days after injury and significant neointimal formation reduction compared to the control group at 7 and 14 days after injury (control group 0.06±0.01 mm2, everolimus group 0.01±0.01 mm2, p<0.01 and control group 0.28±0.06 mm2, everolimus group 0.08±0.03 mm2, p0.01).
CONCLUSION: Oral everolimus reduces adventitial cell activation and neointima formation in balloon injured rat carotid arteries.

Keywords: Everolimus, Restenosis, Angioplasty

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