Journal List > Korean Circ J > v.34(1) > 1074637

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Han, Doo, Cho, Hong, Han, Lee, Oh, Ryu, Rim, Lee, and Lee: Depressed Inflammatory Response to Repeated Angioplasty in Unstable Angina Patients with an In-Stent Restenosis
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Korean Circulation Journal

Korean Circulation Journal 2004; 34(1): 41-46.

Published online: 31 January 2004

DOI: https://doi.org/10.4070/kcj.2004.34.1.41

Depressed Inflammatory Response to Repeated Angioplasty in Unstable Angina Patients with an In-Stent Restenosis

Sang Jin Han, Young Cheoul Doo, Goo Yung Cho, Kyung Soon Hong, Kyoo Rok Han, Nam Ho Lee, Dong Jin Oh, Kyu Hyung Ryu, Chong Yun Rim, Kwang Hahk Lee, Yung Lee

Division of Cardiology, Department of Internal Medicine, Kang-Dong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

ycdoo97@hallym.or.kr

Copyright © 2004 The Korean Society of Circulation

Abstract

BACKGROUND: Inflammation plays a key role in the pathogenesis of an in-stent restenosis because it promotes neointimal proliferation. This study was performed to determine responses of the C-reactive protein (CRP) in unstable angina patients with an in-stent restenosis undergoing repeated percutaneous transluminal coronary angioplasty (re-PTCA).
METHODS: The study subjects (unstable angina) were classified into 2 groups:Group A (n=30, 15 men, mean age 62 years) had a re-PTCA for an in-stent restenosis lesion and Group B (n=60, 33 men, mean age 63 years) underwent a stent implantation for a de novo lesion.
RESULTS: The baseline CRP levels in group A were significantly lower than in group B, as well as 6 and 24 hours after intervention. Twenty four hours after intervention, the CRP levels increased (>4 mg/L) in 3 out of 30 patients (10%) of group A but increased in 32 out of 60 patients (53%) in group B (p<0.001). The differences in the CRP levels between the baseline and 24 hours after intervention were significantly lower in group A than in group B (0.8 and 2.15 mg/L, respectively, p<0.001). In group B, the serum CRP levels 24 hours after intervention were significantly higher than the baseline levels (p<0.05), but not in group A.
CONCLUSION: The CRP expression level is significantly lower in unstable angina patients undergoing a re-PTCA for an in-stent restenosis than those undergoing a stent implantation for a de novo lesion.

Keywords: C-reactive protein, Coronary restenosis, Stents, Angioplasty

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