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Kim, Sung, Park, Kim, Kim, Kang, Lee, Park, Park, Keum, Ryu, and Beck: The Effect of Systemic Inflammation on the Elevation of Troponin I after Percutaneous Transluminal Coronary Angioplasty with Stent in Patients with Stable Angina
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Korean Circulation Journal

Korean Circulation Journal 2004; 34(3): 265-270.

Published online: 31 March 2004

DOI: https://doi.org/10.4070/kcj.2004.34.3.265

The Effect of Systemic Inflammation on the Elevation of Troponin I after Percutaneous Transluminal Coronary Angioplasty with Stent in Patients with Stable Angina

Young Choon Kim, Ki Chul Sung, Seung Ha Park, Byung Jin Kim, Bum Soo Kim, Jin Ho Kang, Man Ho Lee, Jung Ro Park, Hyo Soon Park, Dong Keuk Keum, Seong Ho Ryu, Sung Ho Beck

Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.

Department of Laboratory Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.

Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Copyright © 2004 The Korean Society of Circulation

Abstract

BACKGROUND AND OBJECTIVES: There is growing evidence that inflammation plays an important role in atherosclerosis and in the elevation of cardiac troponin I (cTnI) after coronary intervention. The aim of this study was to evaluate the relationship between inflammatory markers and the elevation of cTnI after coronary intervention in patients with stable angina.
SUBJECTS AND METHODS: Twenty-three patients who underwent successful percutaneous transluminal coronary angioplasty with stent were examined as the subjects. Serial blood samples were obtained for High Sensitivity C-reactive protein (hs-CRP), which served as markers of systemic inflammation, and cTnI. The difference of cTnI before and 24 hours after coronary intervention was defined as the gradient of cTnI.
RESULTS: The mean gradient of cTnI was 1.77±3.4 ng/mL. The concentrations of baseline and post-procedural hs-CRP were 1.57±1.3 mg/L and 6.31±3.8 mg/L, respectively (p=0.001). There were no significant differences in the gradient of cTnI with hypertention, diabetes, smoking, and hypercholesterolemia. The variable that significantly correlated with the gradient of cTnI was the baseline hs-CRP (R2=0.374, p=0.048).
CONCLUSION: Systemic inflammation correlated with periprocedural elevation of cTnI in stable angina patients. These results suggest that inflammation plays a pivotal role in the predictive value of myocardial injury after coronary intervention.

Keywords: C-reactive protein (CRP), Troponin I, Angina pectoris, Stents

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