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Park, Park, Park, Park, Kim, Na, Shin, Suh, Hong, Park, Lim, Kim, Seo, Oh, and Ro: Relation of Blood Pressure Components to Left Ventricular Hypertrophy and Coronary Heart Disease with Aging
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Korean Circulation Journal

Korean Circulation Journal 2004; 34(2): 142-150.

Published online: 28 February 2004

DOI: https://doi.org/10.4070/kcj.2004.34.2.142

Relation of Blood Pressure Components to Left Ventricular Hypertrophy and Coronary Heart Disease with Aging

Jae Suk Park, Chang Gyu Park, Mi Young Park, Jae Hyoung Park, Yong Hyun Kim, Jin Oh Na, Sung Hee Shin, Soon Yong Suh, Soon Jun Hong, Sung Mi Park, Hong Euy Lim, Eung Joo Kim, Hong Seok Seo, Dong Joo Oh, Young Moo Ro

Department of Internal Medicine, Korea University Medical College, Seoul, Korea.

Copyright © 2004 The Korean Society of Circulation

Abstract

BACKGROUND AND OBJECTIVES: There is still uncertainty regarding the relative importance of systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) in predicting the risk of cardiovascular disease. The relative importance of the BP components, as markers of left ventricular hypertrophy (LVH) and coronary artery disease (CAD), were examined in relation to age.
SUBJECTS AND METHODS: In 257 subjects receiving no antihypertensive medication, LVH was determined using the M-mode echocardiography when left ventricular mass index (LVMI) was >or =129 g/m2 in men or >or =118 g/m2 in women. In a further 265 subjects, CAD was determined using the coronary angiography when stenosis of the coronary arterial diameter was >or =70%. The most important BP component was determined using a logistic regression analysis.
RESULTS: With respect to LVH, in the group <0 years of age, odds ratios (ORs) per 10 mmHg increment in BP were 2.47 (p<.01), 1.77 (p<.01), 1.30 (p>0.10) for DBP, SBP and PP respectively. In the group 50 to 59 years of age, ORs were 1.65, 1.35, 1.36 (all p<.05) for DBP, SBP and PP respectively. In the group >or =60 years of age, ORs were 1.56 (p<.05), 1.67, 2.17 (both p<.01) for DBP, SBP and PP respectively. With respect to CAD, in all age group, ORs were 0.93 (p>0.10), 1.07 (p>0.10), 1.21 (p<.05) for DBP, SBP and PP respectively. In the group >or =60 years of age, no BP component had a statistical significance.
CONCLUSION: With increasing age, there was a gradual shift from DBP to SBP and then to PP as the marker with the greatest relation to LVH. In all age group, PP was the strongest marker of CAD.

Keywords: Blood pressure, Pulse pressure, Left ventricular hypertrophy, Coronary artery disease

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