Journal List > Korean Circ J > v.33(12) > 1074439

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Hong, Park, Park, Ahn, Shin, Park, Lim, Kim, Seo, Oh, Ro, and Jang: The Relationship between Serum Adiponectin, Essential Hypertension, LV Mass Index, and LV Diastolic Function
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Korean Circulation Journal

Korean Circulation Journal 2003; 33(12): 1126-1133.

Published online: 31 December 2003

DOI: https://doi.org/10.4070/kcj.2003.33.12.1126

The Relationship between Serum Adiponectin, Essential Hypertension, LV Mass Index, and LV Diastolic Function

Soon Jun Hong, Chang Gyu Park, Jae Suk Park, Jeong Cheon Ahn, Sung Hee Shin, Sung Mi Park, Hong Euy Lim, Eung Joo Kim, Hong Seok Seo, Dong Joo Oh, Young Moo Ro, Yangsoo Jang

Division of Cardiology, Korea University Medical College, Seoul, Korea.

Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Copyright © 2003 The Korean Society of Circulation

Abstract

Background and Objectives

Adiponectin is known for its anti-inflammatory and anti-atherogenic effects. The purpose of this study is to characterize the relationships among serum adiponectin, essential hypertension (EH), left ventricular mass index (LVMI), and LV diastolic function.

Subjects and Methods

Serum adiponectin by RIA and body mass index were measured in 275 patients (M: F=137: 138). We calculated LVMI, E/A ratio, deceleration time (DT), and isovolumetric relaxation time (IVRT) by using echocardiograms.

Results

The serum adiponectin level of the hypertensive group was significantly lower than that of the non-hypertensive group (9.9±9.8 ug/mL vs. 12.9±9.5 ug/mL, p<0.05). Plasma adiponectin was negatively correlated with LVMI (r=-0.329, p<0.001), BMI (r=-0.290, p<0.001), and IVRT (r=-0.485, p<0.05), but was positively correlated with E/A (r=+0.359, p<0.001).

Conclusion

These results suggest that a decrease in serum adiponectin is associated with an increase in blood pressure and BMI, progress of LVH, and decrease in LV diastolic function.

Keywords: Adiponectin, Hypertension, Left ventricular hypertrophy

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