Compartment syndrome is the term used to describe the constellation of clinical symptoms and signs associated with pathophysiologically elevated intracompartmental pressure. It is an infrequent but serious complication of the revascularization of peripheral arterial disease, encountered in surgical bypass and thrombolytic procedures. We present two cases of intraarterial thrombolysis and percutaneous transluminal intervention of the lower extremity arteries, complicated by the development of compartment syndrome.