Journal List > Korean Circ J > v.32(1) > 1074320

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Park, Chae, Choi, Ju, Oh, Kim, Sohn, Oh, Lee, Park, and Choi: The Relationship of the C-514T Polymorphism of the Human Hepatic Lipase Gene Promoter with Plasma HDL-C Concentrations in Koreans
Original Article
Korean Circulation Journal

Korean Circulation Journal 2002; 32(1): 25-30.

Published online: 31 January 2002

DOI: https://doi.org/10.4070/kcj.2002.32.1.25

The Relationship of the C-514T Polymorphism of the Human Hepatic Lipase Gene Promoter with Plasma HDL-C Concentrations in Koreans

Kyung Woo Park, In Ho Chae, Jin Ho Choi, Jae Ran Ju, Seil Oh, Cheol Ho Kim, Dae Won Sohn, Byung Hee Oh, Myoung Mook Lee, Young Bae Park, Yun Shik Choi

Heart Research Institute, Seoul National University Medical Research Institute, Seoul, Korea.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Cardiovascular Research Laboratory, Seoul National University Hospital, Seoul, Korea.

ihchae@snu.ac.kr

Copyright © 2002 The Korean Society of Circulation

Abstract

Background and Objectives

Hepatic lipase is a key enzyme in high density lipoprotein-cholesterol (HDL-C) metabolism and may therefore influence the susceptibility to coronary artery disease (CAD). Furthermore, there seems to be genetic variation in the - 514T allele frequency among different races.

Subjects and Methods

To assess the -514T allele frequency in Koreans, 99 subjects (54 patients with coronary artery disease & 45 normal controls) were examined by polymerase chain reaction (PCR) and restriction enzyme digestion. The lipid profiles of the subjects were also obtained.

Results

The -514T allele frequency was 0.33 in the CAD group and 0.41 in the normal controls, results which are higher than the equivalent reported for Caucasians. The plasma lipid profiles did not differ significantly between genotypes.

Conclusion

These data indicate that the Koreans in this study have a higher -514T allele frequency than that reported for Caucasians. This elevation may be partly responsible for the higher HDL-C level in Koreans, although such polymorphism does not seem to significantly influence plasma HDL-C levels or CAD susceptibility.

Keywords: Lipase, Polymorphism, Lipoproteins, Coronary disease

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