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Chang and Lee: Clinical Study on the Effects of Antihypertensive Drugs
Original Article
Korean Circulation Journal

Korean Circulation Journal 1973; 3(2): 45-56.

Published online: 31 December 1973

DOI: https://doi.org/10.4070/kcj.1973.3.2.45

Clinical Study on the Effects of Antihypertensive Drugs

Rin Chang, M.D., Sung Ho Lee, M.D.

Copyright © 1973 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Evaluation of several antihypertensive regimens involving reserpine, hydrochlorothiazide (Esidrex®) and clonidine (Catapres®) was conducted on 230 subjects with mild to severe hypertension. Chlordiaxepoxide (Librium®) which is a sedative was also administered to observe the effect in patients with mild labile hypertension.
The results obtained were as follows;
1. All five regimens of chlordiazepoxide, reserpine, hydrochlorothiazide, hydrochlorothiazide plus reserpine and hydrochlorothiazide plus clonidine produced a significant decrease in average mean arterial pressure (systolic+diastolicc pressure/2) compared to control values (p<0.01).
2. Hydrochlorothiazide plus clonidine was the most effective pressure lowering regimen, resulting in an average fall of 39.3 mmHg in average mean arterial pressure and obtaining excellent result in 28.6% of the cases.
3. The order in the pressure lowering effect was hydrochlorothiazide plus clonidine, hydrochlorothiazide plus reserpine, hydrochlorothiazide, reserpine, and chlordiazide
4. There was no significant difference between hydrochlorothiazide plus clonidine and hydrochlorothiazide plus reserpine (p>0.1).
5. More reduction in diastolic pressure than systolic was observed with hydrochlorothiazide plus clonidine.
6. The results of hydrochlorothiazide alone, hydrochlorothiazide-reserpine and hydrochlorothaizide-clonidine were better than those of chlordiazepoxide and reserpine alone in patients with fundoscopic findings of Keith-Wagener Grade II.
7. There was difference in pressure lowering effect with hydrochlorothiazide plus clonidine between the group with and without albuminuria.
8. Hydrochlorothiazide plus clonidine were extremely effective in patients with severe hypertension, hydrochlorothiazide plus reserpine in patients with moderately severe hypertension, and reserpine and hydrochlorothiazide alone in patients with mild hypertension.

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