One of the major limitations in coronary intervention is restenosis. This study was aimed to identify clinical, angiographic and procedural factors, which may be related to the second restenosis (SR).

We studied 101 patients who underwent more than two follow-up coronary angiograms after two coronary interventions between Jan 1996 and Dec 1998 in Chonnam University Hospital (out of 4092 total coronary interventions in 3030 patients during the same period). The patients were divided into two groups according to the evidence of second restenosis (SR). Fifty two patients (Group A: 56.6±9.9 year, M: F=44:8) who had SR, and the other 49 patients (Group B: 53.8±8.5 year, M: F=44: 5) were analyzed. Clinical features, angiographic characteristics, coronary interventional procedures, and other risk factors were compared between two groups by univariate analysis and multivariate stepwise logistic regression analysis for the predictive factors of second restenosis.

1) The clinical variables of age, sex, clinical diagnosis, and risk factors were not different between two groups. 2) The lesion types severer than B₂ by AHA/ACC classification were associated with SR (p<0.05). 3) Recurrent angina as an indication for follow up angiography was associated with SR (p<0.01).

The predictive factors associated with SR were patient's subjective symptom and lesion severer than type B₂ according to AHA/ACC classification.