The purpose of this study is to assess the ability of dipyridamole^99mTc-MIBI SPECT to identify and localize coronary artery disease(CAD).

The study population consists of 60 patients(37 males, 23 females : mean age 57±10 years) including 30 with prior myocardial infarction who underwent both dipyridamole^99mTc-MIBI SPECT and coronary angiography for the evaluation of chest pain.

The sensitivities for detection of CAD(≥50% and ≥70% coronary stenosis by angiography) by dipyridamole^99mTc-MIBI SPECT are 96% and 98% respectively, and specifities are 71% and 73% respectively. The sensitivities for detection of individual diseased vessels(≥50% and ≥70%) are 79% and 90% for left anterior descending artery(LAD), 53% and 59% for left circumflex artery(LCX), 45% and 53% for right coronary artery(RCA), 64% and 77% for LCX/RCA, 63% and 72% for total. The specificities for detection of individual diseased vessels(≥50% and ≥70%) are 62% for LAD, 98% and 98% for LCX, 92% and 89% for RCA, 91% and 89% for LCX/RCA, 87% and 86% for total. The concordances for ditection of individual didseased vessels beteen coronary angiography and dipyridamole^99mTc-MIBI SPECT are all fair for SAD(Kappa=0.4 in ≥50% stenosis, 0.54 in ≥70% stenosis)LCX(Kappa=0.56,0.63),RCA(Kappa=0.4,0.44) and LCX/RCA(Kappa=0.56,0.67).

Dipyriddamole^99mTc-MIBI SPECT appers to be an useful noninvasive test for both identification and localization of coronary artery disease.