Abstract
Background
Hypertension is the major risk factor for cardiovascular disease. The increased left ventricular mass has been recognized as an independent predictor of morbidity and mortality in hypertensive patients. The assessment of the regression of left ventricular(LV) mass after antihypertensive therapy offers prognostic information. 2D echocardiography has proved a sensitive tool for the detection of the change of LV mass.
Method
LV mass and LV mass index were measured by area-length method of 2D echocardiography in 26 hypertensive patients and 10 normal control to evaluate the effect of betablocker(group I, n=16) and angiotensin converting enzyme(ACE) inhibitor(group II, n=10) on the regression of LV mass.
Result
There was a significant increase of LV mass and LV mass index in the hypertensive patients(199.0±37.7gm, 119.2±21.2gm/m2) compaired to the control(129.7±11.7gm, 87.4±8.8gm/m2)(p<0.01, p<0.01). After 13.1 week treatment, LV mass was significantly decreased in group I(200.9±35.3gm vs 164.7±25.4gm)(p<0.01) and group II(195.9±43.3gm vs 152.4±27.1gm)(p<0.01). The LV mass index was also significantly decreased in group I(120.3±20.7gm/m2 vs 98.8±15.5gm/m2)(p<0.01) and group II(117.5±22.9gm/m2 vs 91.5±13.6gm/m2)(p<0.01).