Journal List > Korean Circ J > v.21(4) > 1072717

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Yoo, Kwon, Lim, Park, Choi, and Lee: Hypotensive Efficacy and Safety of Ramipril on the Patients with Essential Hypertension
Original Article
Korean Circulation Journal

Korean Circulation Journal 1991; 21(4): 774-780.

Published online: 31 August 1991

DOI: https://doi.org/10.4070/kcj.1991.21.4.774

Hypotensive Efficacy and Safety of Ramipril on the Patients with Essential Hypertension

Won Sang Yoo, M.D., Sung Woon Kwon, M.D., Chang Young Lim, M.D., Sang Hyun Park, M.D., Suck Koo Choi, M.D., Dong Chul Lee, M.D.

Copyright © 1991 The Korean Society of Circulation

Abstract

Thirty three patients with mild to moderate essential hypertension were administered ramipril, a new ACe inhibitor, 2.5-5mg once daily for 6 weeks to evaluate the hypotensive efficacy and safety.
The results were as follows :
1) The patients consisted of 18 males, 15 females, aged 54 on average and classified as mild in 19 and moderate in 14 patients.
2) At the end of 6 weeks trial, blood pressure dropped 13/6mmHg on average, rewarding 70% effectiveness and normalized below 150/90mmHg in 39%.
3) The most frequent side reaction was dry cough in 5 patients(15%) followed by asthenia, GI trouble, dizziness, edema, eye injection and one case of GPT elevation which normalized after completion of trial.
4) The rating of safety of safety was 79% and of overall usefulness was 73%. In conclusion, ramipril 5mg once daily regimen is well tolerated and effective in the treatment of mild to moderated essential hypertension.

Keywords: Ramipril, Essential hypertension

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