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Yoo, Jeon, Park, Lim, and Choi: Hypotensive Efficacy and Safety of Manidipine on the Patient with Essential Hypertension
Original Article
Korean Circulation Journal

Korean Circulation Journal 1991; 21(2): 350-355.

Published online: 30 April 1991

DOI: https://doi.org/10.4070/kcj.1991.21.2.350

Hypotensive Efficacy and Safety of Manidipine on the Patient with Essential Hypertension

Won Sang Yoo, M.D., Young Bin Jeon, M.D., Sang Hyun Park, M.D., Chang Young Lim, M.D., Suck Koo Choi, M.D.

Copyright © 1991 The Korean Society of Circulation

Abstract

Thirty patient with essential hypertension were administered Manidipine, a new calcium antagonist, 10~20mg once daily to evaluate the hypotensive efficacy and safety for 8 weeks. And the followings were the result.
1) Patients were consists of 14 male, 16 female, aged 53 in average and classified as mild in 21 and moderate in 9 patients.
2) Optimum intial dose was 10mg and 10 to 20mg were the doses recommended.
3) Blood pressure dropped after 8 weeks 24/13mmHg in average, rewarding 80% effectiveness and normalized in 87%.
4) Most frequent side reaction was facial flushing in 5 patiens followed by palpitation and dizziness, all of which did not disturb the continuation of medication.
5) Most of routine laboratory parameter were normal and unchanged between before and after the trial.
6) Overall rating of usefulness was 77%.
In conclusion, Manidipine 10 to 20mg once daily regimen is well tolerated and effective in the treatment of mild to moderate essential hypertension.

Keywords: Manidipine, Essential hypertension

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