Baseline blood pressure after 4 weeks with placebo was 150.4±7.5/102.0±4.3mmHg. The blood pressures of the patients were declined significantly at 4th(140.6±14.9/95.4±6.5), 8th(136.7±11.4/91.7±7.6), and 12th(132.3±11.1/87.5±6.9) week(p<0.01) without change of heart rate.

The blood pressure of the patients was normalized below 140/30mmHg in 24 patients(80%) and declined diastolic blood pressure more than 10mmHg in one patients. Therefore the response rate of perindopril was 83.3%. There were reported 3 patients who revealed mild adverse reactions as follows; cough, indigestion, dizziness in one each.

In conclusion, these results indicate that antihypertensive therapy with perindopril single daily dose was effective in patients with mild to moderate essential hypertension and well tolerated.