Journal List > Korean Circ J > v.21(6) > 1072639

Kwon, Kim, Jang, Lim, Sin, Kim, and Kim: A Study of Antihypertensive Effect of Amlodipine

Abstract

We evaluated the antihypertensive effect of amlodipine, a calcium channel bloker, in 35 cases of essential hypertention. After 12 weeks' administration(5~10mg q.d.), the following results were obtained :
1) The systoloic and diastolic blood pressure were decreased significantly(170.3±12.2mmHg vs 143.7±13.0mmHg p<0.01 and 104.7±5.9mmHg vs 87.8±6.5mmHg, p<0.01, respectively) but the heart rate was independant of amlodipine administration.
2) The systolic blood pressure was lowered by 20mmHg or more in 26(76.5%) of 34 patients and the diastolic pressure was lowered by 10mmHg or more in 26(76.5%) of 34 patients at 12 weeks after amlodipine administration.
3) The adverse effects of amlodipine were dizziness in 5, edema in 5, indigestion in 3, constipation in 2, headache, flushing, insomnia in 1 patient respectively and only one of them discontinued amlodipine administration due to severs facial flushing and skin eruption.

TOOLS
Similar articles