Methods : Dipyridamole ^99mTc-MIBI myocardial scintigraphy and coronary angiography on 43 subjects who were suspected to have coronary artery disease. The peripheral hemodynamic response was graded as absent(group 0) if there was a ≤10mm fall in systolic blood pressure (SBP) and/or ≤10 beats/min rise in geart rate(HR) ; moderate(group 1) if there was >10 but ≤20mm fall in SBP and/or >10 but ≤20 beats/min rise in HR ; and marked (group 2) if there was >20mm fall in SBP and/or >20 beats/min rise in HR.

Results : The overall diagnostic sensitivity and specificity for coronary artery disease of dipyridamole perfusion scintigraphy were 68%, 83% while per vessel sensitivity and specificity for coronary artery disease were 66%, 97%. The numbers of induced chest pain and ischemic ST changes among hemodynamic subgroups, were 40%, 40% in group 0, 33%, 27% in group 1 and 50%, 40% in group 2 without significant difference in each hemodynamic subgroups. Either the numbers of diseased coronary arteries or the numbers of patients demonstrationg reversible scintigraphic defects were not statically different among each subgroups.

Conclusions : Although the peripheral hemodynamic response dose not always correlate with its central coronary effect but dipyridamlole ^99mTc-MIBI myocardial perfusion scintigraphy is an useful test for diagnosis of coronary artery disease.