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Yoo, Lee, Ahn, Kim, Lee, Rhee, and Choi: Effect of Lovastatin(Mevacor®) on Serum Lipids of Patients with Primary Hyperlipidemia
Original Article
Korean Circulation Journal

Korean Circulation Journal 1989; 19(3): 489-496.

Published online: 30 September 1989

DOI: https://doi.org/10.4070/kcj.1989.19.3.489

Effect of Lovastatin(Mevacor®) on Serum Lipids of Patients with Primary Hyperlipidemia

Won Sang Yoo, M.D., Sung Bong Lee, M.D., Jeong Hyo Ahn, M.D., Kyun Kim, M.D., Dong Chull Lee, M.D., Kun Joo Rhee, M.D., Suck Koo Choi, M.D.

Copyright © 1989 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new hypolipidemic agent, lovastatin, hydroxy-methyl-gultaryl coenzyme A reductase inhibitor was administred to 25 patients with primary hyperlipidemia 20 to 40 mg daily for 12 weeks and sequential changes of serum lipid profile were analysed as follow.
1) Mean average at baseline period of serum total cholesterol, triglyceride, HDL and low desity lipoprotein cholesterol were 271, 179, 51 and 185 mg/dl respectively.
2) Total cholesterol showed 20% decrease at 4th week and 23% decrease at the end of 12th week while low density lipoprotein cholesterol decreased 31% and 33% respectively.
3) Triglyceride dropped 7% at 8th week and 3% at 12th week. High density lipoprotein cholesterol increased 4% at 4th week and showed 2% decrease at the end of study.
4) Only one patient complained of moderate abdominal pain, which subsided after 2 weeks drug withdrawal.
In conclusion, lovastatin was well tolerated and effective, in the treatment of primary hyperlipidemia.

Keywords: Lovastatin, Hyperlipidemia

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