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Jeon and Ro: Clinical Effects of Isosorbide 5-Mononitrate(Elantan®) on Angina Pectoris
Original Article
Korean Circulation Journal

Korean Circulation Journal 1989; 19(3): 483-488.

Published online: 30 September 1989

DOI: https://doi.org/10.4070/kcj.1989.19.3.483

Clinical Effects of Isosorbide 5-Mononitrate(Elantan®) on Angina Pectoris

Eun Seok Jeon, M.D., Heung Kyu Ro, M.D.

Copyright © 1989 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antianginal effects of oral isosorbide 5-mononitrate(Elantan®) were evaluated in 14 patients with angina pectoris by repeated treadmill exercise test before and after oral Elatan® therapy(49 mg/day for 14 days) in Chungnam National University Hospital from Dec., 1988 to Jun., 1989.
The results were as follows;
1) The patients were 45 to 71 years old(mean 57) and consisted of 9 men and 5 women.
2) There were no significant effects on resting hemodynamic data such as heart rate, systolic and diastolic blood pressure after Elatan® therapy.
3) Peak heart rate, peak blood pressure and peak heart rate-systolic blood pressure product(double prduct) during exercise showed no changes.
4) Exercise durations were prolonged in 11(79%) patients, did not changed in 2(14%), and shorted in 1(7%) patient after therapy(399±189 seconds vs 529±230, second P<0.01).
5) Three patients complained of headache, but none discontinued medication.

Keywords: Isosorbide 5-mononitrate, Angina pectoris

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