Journal List > Korean Circ J > v.19(2) > 1072477

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Kim, Kim, Kim, Do, Park, Sohn, Ryu, Oh, Park, Choi, Seo, and Lee: Thrombolysis by Recombinant Tissue-Type Plasminogen Activator in Patients with Acute Myocardial Infarction
Original Article
Korean Circulation Journal

Korean Circulation Journal 1989; 19(2): 229-236.

Published online: 30 June 1989

DOI: https://doi.org/10.4070/kcj.1989.19.2.229

Thrombolysis by Recombinant Tissue-Type Plasminogen Activator in Patients with Acute Myocardial Infarction

Duk Kyung Kim, M.D., Jae Joong Kim, M.D., Cheol Ho Kim, M.D., Moon Hong Do, M.D., Sung Wook Park, M.D., Dae Won Sohn, M.D., Kyu Hyung Ryu, M.D., Byung Hee Oh, M.D., Young Bae Park, M.D., Yun Shik Choi, M.D., Jung Don Seo, M.D., Young Woo Lee, M.D.

Copyright © 1989 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myocardial infarction is usually associated with thrombotic occlusion of an artherosclerotic coronary artery. Reperfusion induced by administration of thrombolytic agents may presserve myocardial function and reduce mortality. At a mean of 272 minutes from symtom onset, 7 patients with acute myocardial infarction received recombinant tissue-type Plasminogen Activator.
The results are as followings:
1) Reperfusion of the infarct-related artery was observed in all of the 5 patients in whom coronary angiography was performed 19 hour after initiation of drug infusion. Ergonovine challenge test, done in 1 patient who showed normal coronary artery, did not induced coronary spasm.
2) The maximal value of Creatine Kinase and Creatine Kinase-MB(2098±2107U/L and 728±532U/L, respectively) occured at 7.2±4.3 hour, respectively. A nadir value of fibrinogen(42±21% of the preinfusion value) occured at 3.1±2.0 hour.
3) Major bleeding episodes occured in 3 patients. Major cardiac events were angina followed by percutaneous transluminal coronary angioplasty in 1 patient; cardiogenic shock in 2 patients, one of whom also experienced recurrent ventricular tachycardia;reinfarction in 1 patient, 3 of the 7 patients died.

Keywords: Acute myocardial infarction, Thrombolysis, Recombinant tissue-type Plasminogen Acivator(rt-PA)

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