Journal List > Korean Circ J > v.19(1) > 1072471

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Jeong, Park, Park, Park, Jeong, Cho, and Kang: Hypotensive Effect of Guanabenz Acetate(Rexitene®)in Essential Hypertension;A Clinical Study
Original Article
Korean Circulation Journal

Korean Circulation Journal 1989; 19(1): 117-124.

Published online: 31 March 1989

DOI: https://doi.org/10.4070/kcj.1989.19.1.117

Hypotensive Effect of Guanabenz Acetate(Rexitene®)in Essential Hypertension;A Clinical Study

Jin Won Jeong, M.D., Yang Kyu Park, M.D., Ock Kyu Park, M.D., Jong Chun Park, M.D., Myung Ho Jeong, M.D., Jeong Gwan Cho, M.D., Jeong Chaee Kang, M.D.

Copyright © 1989 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To evaluate the hypertensive effect of guanbenz acetate, we performed a prospective clinical study for 10 weeks or more in 27 patients with essential hypertension(mean age: 51, mean supine blood pressure: 176/105mmHg). The daily dose of guanabenz acetate was 8-49 mg.
The results were as follows;
1) After 2, 4, 6 and 8 weeks of treatment, average supine systolic and diastolic blood pressures reduced to 156/94, 150/94, 149/93 and 144/93mmHg respectively(all P<0.05).
2) Pulse rate decreased slightly from pre-treatment average of 75 beats per minute to 71 beats per minute at the end of the study(P<0.05).
3) Average body weight, serum levels of total cholesterol, AST, ALT, BUN, creatinine, sodium and potassium were not significantly changed from pre-treatment values.
4) A few side effects in order of frequency were dry mouth, dizziness, sedation, weakness, etc.
We conclude that guanabenz acetate may be used as an effective first line antihypertensive agent in essential hypertension.

Keywords: Guanabenz acetate, Essential hypertension

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