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Jeong, Shin, Yang, Park, Cho, Park, Kang, and Park: The Difference of the Rate of Regression of the left Ventricular Mass between the Age Groups in the Hypertensive Patients with the Left Ventricular Hypertrophy with the Control of Blood Pressure by Angiotensin Converting Enzyme Inhibitor
Original Article
Korean Circulation Journal

Korean Circulation Journal 1988; 18(4): 605-612.

Published online: 31 December 1988

DOI: https://doi.org/10.4070/kcj.1988.18.4.605

The Difference of the Rate of Regression of the left Ventricular Mass between the Age Groups in the Hypertensive Patients with the Left Ventricular Hypertrophy with the Control of Blood Pressure by Angiotensin Converting Enzyme Inhibitor

Myung Ho Jeong, M.D., Soon Chul Shin, M.D., Seung Jin Yang, M.D., Chan Hyung Park, M.D., Jeong Gwan Cho, M.D., Jong Chun Park, M.D., Jung Chaee Kang, M.D., Ock Kyu Park, M.D.

Copyright © 1988 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The left ventricular hypertrophy(LVH) in the hypertensive patients is known to be associated with relatively higher risk for cardiovascular morbidity and mortality. In this sense the reversal of LVH with blood pressure control, if attained, could yeild an additional benefit of reducing cardiovascular morbidity and/or mortaility associated with hypertension. However pathogenesis of LVH, the attitude of the LVH to regerss with blood pressure control in a particular patient and whether the regression is really beneficial are not clear.
In order to see the effect of angiotensin converting enzyme(ACE) inhibitors on LVH and the age group difference of the LVH regresion, if attainable, 26 hypertensive patients with LVH(LVMI:Left Ventricular Mass Index>125g/m2) were treated with enalapril or captopril for more than 12 weeks and the LVMI followed and the regression rates in younger group "A"(less than 50 years of age) and elder group "B" were compared(LVMI, level of blood pressure, kinds and dosage of enalapril or captopril were not different between the two groups).
The LVMI was significantly decreased in both groups, in group A from 191.6±74.9g/m2 to 139.7±52.0g/m2, and in group B from 185.5±58.7g/m2 to 163.9±58.7g/m2. In group A the percent decrease of LVMI was significantly higher than that of group B(25.3±14.9% versus 10.3±8.6%, p<0.005).
Above results suggest that enalapril and captopril are equally effective in reducing LVMI in hypertensive patients with LVH and the regression of the LVMI is more marked in the younger age group in this relatively short-term treated small population study.

Keywords: LVM regression, Antiyhpertensive treatment, ACE inhibitors

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