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Son, Shim, Kim, Lim, Lee, and Lee: Clinical Trial on the Antianginal Effect of Trapidil
Original Article
Korean Circulation Journal

Korean Circulation Journal 1988; 18(2): 251-255.

Published online: 30 June 1988

DOI: https://doi.org/10.4070/kcj.1988.18.2.251

Clinical Trial on the Antianginal Effect of Trapidil

Joo Hyun Son, M.D., Jong Geol Shim, M.D., Jeong Hyun Kim, M.D., Heun Kil Lim, M.D., Bang Hun Lee, M.D., Chung Kyun Lee, M.D.

Copyright © 1988 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antianginal effect of Trapidil was evaluated in 30 patients (18 male and 12 females) with angina rectoris.
The results were follows :
1) Antianginal effect of the drug were good in 18 cases (60%) and fair in 8 cases (37%), and there was no effect in 4 cases(13%).
2) Improvement in ECG changes was observed in 29%.
3) There were no significant change in CBC, RUA, LFT, serum electrolyte and lipid study before and after medication.
4) The adverse effects of trapidil were constipation, gastric cramp and dizziness, respectively one case. But they were not required discontinuing the medicetion.
On the basis of these results, Trapidol was evaluated to be promising antianginal drug.

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