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Yun, Koh, Kim, Lim, Lee, and Lee: Radionuclide Evaluation of Left and Right Ventricular Function with Intravenous Verapamil Administration in Essential Hypertension
Original Article
Korean Circulation Journal

Korean Circulation Journal 1988; 18(2): 199-206.

Published online: 30 June 1988

DOI: https://doi.org/10.4070/kcj.1988.18.2.199

Radionuclide Evaluation of Left and Right Ventricular Function with Intravenous Verapamil Administration in Essential Hypertension

Ho Ju Yun, M.D., Youn Suck Koh, M.D., Jung Hyun Kim, M.D., Heon Kil Lim, M.D., Bang Hun Lee, M.D., Chung Kyun Lee, M.D.

Copyright © 1988 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effects of intravenous Verapamil administration on ventricular function were evaluated using grated radionuclide ventriculography in 15 patients with essential hypertension. Verapamil(0.1mg/kg) was injected as a bolus for 2 minutes followed by an infusion of 0.007mg/kg/min. Heart rate, blood pressure, ejection fraction, peak ejection rate, total filling time, and prak filling rate were assessed before and after Verapamil administration.
The results were was as follows ;
1) Verapamil administration increased heart rate from 63±5 to 75±9 beats/min(p<0.01) and reduced systolic and diastolic blood pressure from 156±17/99±6mmHg to 139±16/88±6mmHg(p<0.01).
2) Ejection fraction, peak ejection rate, and total filling time were not changed significantly after Verapamil injection.
3) Right and left ventricular peak filling rate increased significantly only in patients in whom it was subnormal in the basal study) from 1.6±0.4 to 2.3±1.1 end-diastolic volumes/s, p<0.05 and from 2.5±0.6 to 3.1±0.8 end-diastolic volumes/s, p<0.05, respectively).
In conclusion, it was found that intravenous Verapamil administration enhances ventricular diatolic function in patients with essential hypertension.

Keywords: Ventricular function, Intravenous Verapamil, Essential hypertension

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