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Seo and Lee: Clinical Study on Antihypertensive Effect of Verapamil
Original Article
Korean Circulation Journal

Korean Circulation Journal 1988; 18(1): 153-158.

Published online: 31 March 1988

DOI: https://doi.org/10.4070/kcj.1988.18.1.153

Clinical Study on Antihypertensive Effect of Verapamil

Bong Kwan Seo, M.D., Jong Suk Lee, M.D.

Copyright © 1988 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antihypertensive effect of verapamil, a calcium channel blocker, was studied in 12 cases of essential hypertension (mean age 49, range 24-64). After 6 weeks administration (80-160mg t.i.d.), the following results were obtained :
1) Before medication, average systolic and diastolic blood pressure was 176.3/108.6mmHg. After completion of therapy, blood presure fell significantly down to 154.8/94.2mmHg (p<0.01).
2) Heart rate decreased slightly from average 74.3 per minute prior to medication to 69.3 per minute at the end of study (p<0.01).
3) Side effects, among which constipation was most common, were mild and did not compel any patient to diacontinue therapy.
In conclusion, verapamil seems to be a safe and effective first-line drug for hypertension along with diuretics or beta blockers.

Keywords: Verapamil, Antihypertensive effect

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