Journal List > Korean Circ J > v.17(4) > 1072397

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Choi, Kim, Kim, Oh, Park, Seo, and Lee: Clinical Effects of Nicorandil on Angina Pectoris
Original Article
Korean Circulation Journal

Korean Circulation Journal 1987; 17(4): 783-788.

Published online: 31 December 1987

DOI: https://doi.org/10.4070/kcj.1987.17.4.783

Clinical Effects of Nicorandil on Angina Pectoris

Yun Shik Choi, M.D., Chul Ho Kim, M.D., Yoo Ho Kim, M.D., Byung Hee Oh, M.D., Young Bae Park, M.D., Jung Don Seo, M.D., Young Woo Lee, M.D.

Copyright © 1987 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effects of oral nicorandil were evaluated in 32 patients with angina pectoris who were diagnosed by typical chest pain and postitive treadmill exercise test from December 1986 throught May 1987.
The effects were measured by clinical improvement rating at 4 and 8 weeks after administration of nicorandil, and by repeated treadmill exercise test in 16 patients.
The results were as follow's:
1) Clinical improvement was observed in 23(71.5%) and 25(78%) of 32 patients at 4 and 8 weeks after oral nicorandil.
2) Repeated treadmill exercise test of 16 patients showed significant prolongation of exercise duration (464±148 seconds vs. 526±174, p<0.05).
3) Hemodynamic data like blood pressure or heart rate were independent of nicorandil administration.
4) Three patients complained of headache, and one of them discontinued nicorandil. Mild indigestion was also found in another one patient.

Keywords: Nicorandil, Angina pectoris

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