Fiftyeight patients with cardiac neurosis were studied to evaluate the effects of Carteolol 10mg/day. Systolic blood pressure was declined to 122.7±17.2mmHg from 137.1±23.2mmHg, diastolic blood pressure was declined to 79.6±11.1mmHg from 88.2±17.5mmHg. Pulse rate was decreased from 83.0±10.2 to 73.9±6.8per minute. The most frequent subjective symptom was palpitation (74.1%) and effectiveness of therapy for subjective symptom was 91.4%, for usefulness was 93.1%. There was no significant serious side reaction observed. We concluded that Carteolol therapy for the patients with cardiac neurosis could be useful and safe with a small dosage.