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Lee, Yoon, Cho, Kang, and Park: A Clinical Study of Hypotensive Effect of Tripamide(Normonal®) in Essential Hypertension
Original Article
Korean Circulation Journal

Korean Circulation Journal 1984; 14(1): 157-163.

Published online: 30 June 1984

DOI: https://doi.org/10.4070/kcj.1984.14.1.157

A Clinical Study of Hypotensive Effect of Tripamide(Normonal®) in Essential Hypertension

Chang Soo Lee, M.D., Young Gun Yoon, M.D., Jeong Gwan Cho, M.D., Jung Chaee Kang, M.D., Ock Kyu Park, M.D.

Copyright © 1984 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The hypotensive effect of tripamide(Normonal®) were evaluated in 31 cases of essential hypertension. Fifteen to thirty mg of tripamide per day were administered continuously for 8 weeks. The results were as follows;
1) The systolic blood pressure was significantly lowered from 175±15 mmHg(Mean±SD) before treatment to 144±17 mmHg after treatment(p<0.01), and the diastolic blood pressure was significantly lowered from 106±11 mmHg before treatment to 90±12 mmHg after treatment(p<0.01).
2) The systolic blood pressure was lowered 20 mmHg or more in 25 out of 31 cases(80.7%), and the diastolic blood pressure was decreased 10 mmHg or more in 25 out of 31 cases(80.7%) at the end of 8 weeks treatement.
3) There was no significantl differences in the level of SGOT, serum cholesterol, serum electrolytes(Na+, K+, Cl-), BUN, creatinine and urinc acid before and after treatment with tripamide.
4) In most cases the subjective symptoms disappeared or became easier after tripamide treatment.
5) Profound weakness was developed in 2 cases during tripamide administration.

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