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Choi and Yoo: Clinical Effect of Nicardipine(Perdipine®) on Cerebrovascular Diseases
Original Article
Korean Circulation Journal

Korean Circulation Journal 1984; 14(1): 151-156.

Published online: 30 June 1984

DOI: https://doi.org/10.4070/kcj.1984.14.1.151

Clinical Effect of Nicardipine(Perdipine®) on Cerebrovascular Diseases

Soo Jeon Choi, M.D., Won Sang Yoo, M.D.

Copyright © 1984 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Twenty-five patients with cerebrovascular diseases were administered Nicardipine, a calcium antagonist, in daily dose of 60 mg per orally for 8-12 weeks during the year of 1983, to evaluate the efficacy of the drugs clinically. The following results were obtained.
1) General improvement rating was 80%.
2) Marked improvement(88%) were noted in subjective symptoms, especially of tinnitus, paresthesia and headache. significant improvement were noted in psychiatric(74%) and neurologic(71%) symptoms e.g disturbance of sleep, emotion, memory, speech, swallowing and muscle power.
3) In 13 hypertensive patients, average blood pressure lowered from 163/96 to 138/83 mmHg in 4 weeks and maintained thereafter.
4) major adverse effect was facial flushing, noted in 4 patients(16%), which were transient and mild and allowed to contiume medication.

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