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Park, Cho, Yoon, Lee, Park, and Kim: Effect of Atenolol on Left Ventricular Function in Essential Hypertension
Original Article
Korean Circulation Journal

Korean Circulation Journal 1983; 13(2): 395-401.

Published online: 31 December 1983

DOI: https://doi.org/10.4070/kcj.1983.13.2.395

Effect of Atenolol on Left Ventricular Function in Essential Hypertension

Ock Kyu Park, M.D., Jeong Gwan Cho, M.D., Young Gun Yoon, M.D., Na Young Lee, M.D., Yang Kyu Park, M.D., Hyung Gon Kim, M.D.

Copyright © 1983 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was made to evaluate the effect of oral atenolol, a cardioselective beta-adrenergic blocking agent without intrinsic sympathomimetic activity, on left ventricular function in patient with essential hypertension. Atenolol, 100mg/day, was given to 11 hypertensive patients for 4 weeks, and its effects on arterial pressure, pulse rate, left ventricular dimensions and ejection phase indices of myocardial performance were examined by echocardiography. Echocardiographic studies were performed before treatment and after 4 weeks of atenolol therapy.
Arterial pressure fell form 145/90 mmHg to 138/84mmHg after 4 weeks. Pulse rate fell significantly from 69/min to 58/min(p<0.05). Left ventricular end-diastolic and end-systolic dimensions and mean rate of circumferential fiber shortening(mVcf) did not change significantly. Ejection fraction increased significantly from 0.66 to 0.72(p=0.01).
This results indicate that atenolol in the resting state has no depressant effect on left ventricular function in patients with essential hypertension.

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