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Ryoo: Effects of Prazosin Alone and in Combination for Treatment of Essential Hypertension
Original Article
Korean Circulation Journal

Korean Circulation Journal 1983; 13(2): 387-394.

Published online: 31 December 1983

DOI: https://doi.org/10.4070/kcj.1983.13.2.387

Effects of Prazosin Alone and in Combination for Treatment of Essential Hypertension

Un Ho Ryoo, M.D.

Copyright © 1983 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The therapeutic effects of prazosin hydrochloride alone and in combination with diuretic and/or beta-blocker in 41 patients with essential hypertension were evaluated.
The results were as follows:
1) Of 28 patients treated with prazosin alone, 18(64.2%) achieved normalization of blood pressure and 7(25.0%) had good response of treatment.
2) Of 16 patients, with inadequate control on initial treatment, treated with prazosin in combination with diuretic and beta-blocker, 14(87.5%) achieved normalization of blood pressure.
3) After therapy with prazosin alone, the mean blood pressure reduced 25/16mmHg(p<0.05/p<0.01).
4) After addition of diuretic or beta-blocker in 6 patients receiving prazosin alone with inadequate response, the mean blood pressure reduced 31/13mmHg(p<0.01/p<0.01).
5) After addition of prazosin in 10 patients receiving diuretic alone or diuretic and beta-blocker but with inadequate control, the mean blood pressure reduced 32/14 mmHg(p<0.01/p<0.01).
6) The side effects were noted in 10 patients(25.0%). The most popular one was dizziness(17.5%), and the next was headache(10.0%).

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