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Song, Cho, Kwon, Jeong, Lee, Kang, and Park: A Clinical Study on the Effect of Bezafibrate in Hyperlipidemia
Original Article
Korean Circulation Journal

Korean Circulation Journal 1982; 12(2): 217-224.

Published online: 31 December 1982

DOI: https://doi.org/10.4070/kcj.1982.12.2.217

A Clinical Study on the Effect of Bezafibrate in Hyperlipidemia

Jong Oh Song, M.D., Jeong Gwan Cho, M.D., Hyun Kwon, M.D., Jin Won Jeong, M.D., Chang Soo Lee, M.D., Jung Chaee Kang, M.D., Ock Kyu Park, M.D.

Copyright © 1982 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The lipid lowering effects of bezafibrate were evaluated in 18 patients with hyperlipidemia, i.e. over 200mg/dl of cholesterol and/or of cholesterol and/or triglyceride before treatment. The materials were 18 patients(male:8, female:10);7 with diabetes mellitus, 8 with congestive cardiomyopathy, 1 with parkinsonism, The serum lipid concents were measured with enzyme method before and 6 weeks after the treatment with daily 600mg of bezafibrate administered per oral and the differences were observed.
1) The level of serum cholesterol was reduced from 262.8mg/dl(±58.9SD) before treatment to 191.3gm/dl(±31.3SD) after 6 weeks treatment(p<03.005).
2) The level of serum triglyceride was reduced from 231.8mg/dl(±104SD) before treatment to 144.4mg/dl(±51SD) after 6 weeks treatment(p<0.005).
3) The level of serum HDL increased from 47.2mg/dl(±19.7SD) before treatment to 61.3mg/dl(±13.9SD) after 6 weeks treatment(p<0.005).
4) The level of serum LDL was reduced from 169.3mg/dl(±52.4SD) before treatment to 101.2mg/dl(±29.5SD) after 6 weeks treatment(p<0.05).
5) HDL/Cholesterol ratio was increased from 17.8%(±5.4SD) before treatment to 32.6%(±7.9SD) after 6 weeks treatment(p<0.005).
6) HDL/LDL ratio was increased from 29.2%(±10.8SD) before treatment to 67.2%(±30.8SD) after 6 weeks treatment(<0.005).
The side effects of bezafibrate such as G-I trouble, myositis, hypersensitivity, elevation of BUN and creatinine were not observed.

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