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Abstract
The effect of Minizide® (prazosine 1mg and polythiazide 0.5mg) was studied in 34 hypertensive patients (female 16 cases, male 18 cases) at the Department of Internal Medicine, Paik Hospital, In-Je Medical College between July, 1979 and August 1980 for 14 months.
The patients didn't take the any drugs for one week before the clinical trial with Minizide®, and thereafter they took minizide 1 tablet 3 times daily for 2 weeks.
The blood pressure was checked before and after the trial in the supine and standing position.
The results were as followings:
1) The systolic blood pressure before the treatment with Minizide in the supine position was 196±24mmHg and in the standing position 188±22mmHg.
The systolic blood pressure after the treatment with minizide in the supine position was 148±16mmHg and in the standing position 139±9mmHg.
2) The diastolic blood pressure before the treatment with minizide in the supine position was 118±11mmHg, and in the standing position 113±10mmHg. The diastolic blood pressure after the treatment with minizide in the supine position was 87±6mmHg and in the standing position 84±5mmHg.
3) There was no significant orthostatic hypotension after the 34 patients.
4) There was no changes of laboratory findings after the treatment.
5) 3 of 34 hypertensive patients after the treatment complained of headache, 3 palpitation, 2 edema, 2 drowsiness, and 1 fatigability and 1 patient complained of weakness.
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