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Seo, Cho, Lee, Kim, Kim, and Lee: Propranolol Hcl in Patients with Angina Pectoris
Original Article
Korean Circulation Journal

Korean Circulation Journal 1971; 1(2): 43-48.

Published online: 31 December 1971

DOI: https://doi.org/10.4070/kcj.1971.1.2.43

Propranolol Hcl in Patients with Angina Pectoris

Jung Don Seo, M.D., Chan Sung Cho, M.D., Young Woo Lee, M.D., Kwang Hoi Kim, M.D., Do Jin Kim, M.D., Sung Ho Lee, M.D.

Copyright © 1971 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A double-blind trial of the efficacy of propranolol hydrochloride a new beta adrenergic blocking agent, in the prophylactic treatment of angina pectoris was conducted in 9 patients. Through the trial period of 8 weeks to more than 26 weeks, the patients received propranolol and placebo for equal period.
Following are the results.
1. The effective dose of propranolol hydrochloride in the prophylactic treatment of angina pectoris was 80 mg to 120 mg per day.
2. The effectiveness of propranolol hydrochloride was manifested by a reduction in frequency of pain to 40.7%, in nitroglycerin comsumption to 38.8% and by an increase in exercise tolerance.
3. Obseved side effects were transient nausea, vomiting and bradycardia, which were improved with reduction in drug dosage.
4. Further clinical and experimental information may be necessary in order to assess the long-term effects of propranolol hydrochloride.

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