Journal List > Korean Circ J > v.1(2) > 1071994

TOOLS
Kang and Park: The Effect of Diphenylhydantoin on the Action of Ouabain
Original Article
Korean Circulation Journal

Korean Circulation Journal 1971; 1(2): 23-26.

Published online: 31 December 1971

DOI: https://doi.org/10.4070/kcj.1971.1.2.23

The Effect of Diphenylhydantoin on the Action of Ouabain

Sung Kyew Kang, M.D., Ok Kyu Park, M.D.

Copyright © 1971 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effect of diphenylhydantoin on LD 50 of ouabain was investigated in frogs, using "one hour frog method".
LD50 of ouabain in control group was 1.90 µg/10g.
A dose of 100 µg/10g diphenylhydantion did not affect the systemic manifestations of the frogs, but increase the LD50 of ouabain to 2.60 µg/10g.
The difference of LD50 of ouabain and potency ratio between control group and diphenylhydantoin-treated group was statistically significant.

TOOLS
Similar articles