A Case of Pediatric Nodal Marginal Zone Lymphoma

Byunghun Min; Joong Kee Youn; Ji-Won Han; Chaeyoun Oh; Hyun-Young Kim; Sung-Eun Jung

doi:10.13029/jkaps.2016.22.2.59

Journal List > J Korean Assoc Pediatr Surg > v.22(2) > 1071974

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Min, Youn, Han, Oh, Kim, and Jung: A Case of Pediatric Nodal Marginal Zone Lymphoma

Case Report

J Korean Assoc Pediatr Surg 2016;22(2):59-62.

Published online: 22 December 2016

DOI: https://doi.org/10.13029/jkaps.2016.22.2.59

A Case of Pediatric Nodal Marginal Zone Lymphoma

Byunghun Min, Joong Kee Youn, Ji-Won Han, Chaeyoun Oh, Hyun-Young Kim, Sung-Eun Jung

Department of Pediatric Surgery, Seoul National University Children’s Hospital, Seoul, Korea

Correspondence: Hyun-Young Kim, Department of Pediatric Surgery, Seoul National University Children’s Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: +82-2-2072-2478, Fax: +82-2-747-5130, E-mail: spkhy02@snu.ac.kr

Received 21 July 2016 Revised 18 October 2016 Accepted 18 October 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lymph node enlargement is a common finding in children suggesting normal or benign. Palpable nodes which are large, hard or fixed must be examined carefully to rule out malignant diseases. In this case, a 15-year-old boy presented to our hospital to inspect the palpable mass at his post-auricular area being found 2 months ago. It was diagnosed as nodal marginal zone lymphoma (NMZL) through excisional biopsy and immunohistochemistry. NMZL is very rare, especially in children and young adults, but occurs locally in most cases with a good prognosis compared to adults. We described a rare case of NMZL diagnosed in adolescent.

Keywords: Lymphoma, Nodal marginal zone lymphoma, Pediatric, Malignant lymphoma, Lymphadenopathy

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Fig. 1.

A palpable, fixed 3×2-cm-sized mass positioning at the left posterior auricular area (arrowheads).

Fig. 2.

Ultrasonographic image showing a hypoechoic lobulated mass, with 2.2×2.4×0.8 cm size and inner vascularity (arrowheads).

Fig. 3.

Immunophenotypic features of excised mass. (A) H&E stain (×40) showing a gross lymphoid tissue with effaced normal follicular architectures suggesting neoplastic rather than reactive condition. (B) With a few normal germinal centers left, it was mostly filled with diffusely grown small to medium-sized atypical cells (H&E stain, ×200). These cells were positive in CD20 (B lymphocyte antigen; C) and Bcl-2 (F) but negative in CD10 (D) and Bcl-6 (E) (C-F: ×40).

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