Intra-amniotic Candida infection is uncommon but the consequence can be catastrophic. Transcervical amphotericin B and intra-amniotic fluconazole administration were identified in the literature. We present a case with intact membranes and ongoing pregnancy treated by maternal intravenous liposomal amphotericin B. A primipara who underwent cerclage placement before fetal viability was diagnosed with intra-amniotic Candida infection. Although maternal intravenous liposomal amphotericin B eradicated fungi in the amniotic cavity, Escherichia coli invasion caused devastating chorioamnionitis. The newborn delivered at 27⁺³ weeks’ gestation did not survive due to respiratory distress syndrome and sepsis. Despite negative conversion of intra-amniotic culture results for fungi after treatment, another pathogen such as bacteria could ascend into the amniotic cavity via weakened membranes. Clinicians should consider broad-spectrum antibiotics as well as antifungal agents in this setting.