Adult Type Granulosa Cell Tumor of the Testis

Dong Jun Kim; Dong Woo Song; Sang Yeop Yi; Woon Yong Yun; Tae Yung Jeong

doi:10.4111/kju.2008.49.1.95

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Kim, Song, Yi, Yun, and Jeong: Adult Type Granulosa Cell Tumor of the Testis

Original Article

Korean J Urol 2008;49(1):95-97.

Published online: 20 January 2008

DOI: https://doi.org/10.4111/kju.2008.49.1.95

Adult Type Granulosa Cell Tumor of the Testis

Dong Jun Kim, Dong Woo Song, Sang Yeop Yi¹, Woon Yong Yun, Tae Yung Jeong

Department of Urology, College of Medicine, Kwandong University, Goyang, Korea

¹Department of Pathology, College of Medicine, Kwandong University, Goyang, Korea

Tae Yung Jeong Department of Urology, College of Medicine, Kwan-dong University, 697-24, Hwajeong- dong, Deokyang-gu, Goyang 412-270, Korea TEL: 031-979-5105 FAX: 031-814-5312 E-mail: urojeong@ kwandong.ac.kr

Received 2 October 2007 Revised 25 October 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Testicular granulosa cell tumor (GCT) is a rare neoplasm. We report here on an incidentally discovered testicular granulosa cell tumor in a 36-year-old man. The serum tumor markers were within the normal limits. The ultrasonographic findings revealed a mass with a heterogenous hypoechoic echotexture, including multiple variable sized cystic components. The histology on the orchiectomy specimen demonstrated a gonadal stromal tumor with granulosa cell features. Testicular granulosa cell tumor of the adult type is a very rare tumor, and there have been several isolated case reports and small serial studies described in the literature.

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Keywords: Testis, Testicular neoplasms, Granulosa cell tumor

References

1. Talerman A. Pure granulosa cell tumour of the testis. Report of a case and review of the literature. Appl Pathol. 1985; 3:117–22.

2. Ditonno P, Lucarelli G, Battaglia M, Mancini V, Palazzo S, Trabucco S, et al. Testicular granulosa cell tumor of adult type: a new case and a review of the literature. Urol Oncol. 2007; 25:322–5.

3. Kee MS, Lee TJ, Huh JR, Park TH, Ro JY. Granulosa cell tumor arising in the paratesticular area. Korean J Pathol. 1999; 33:380–4.

4. Paik SY, Kang HY, Han JH, Yang WI, Han SJ. Juvenile granulosa cell tumor arising in undescended testis. Korean J Pathol. 1999; 33:376–9.

5. Jimenez-Quintero LP, Ro JY, Zavala-Pompa A, Amin MB, Tetu B, Ordonez NG, et al. Granulosa cell tumor of the adult testis: a clinicopathologic study of seven cases and a review of the literature. Hum Pathol. 1993; 24:1120–5.

6. Wang BY, Rabinowitz DS, Granato RC Sr, Unger PD. Gonadal tumor with granulosa cell tumor features in an adult testis. Ann Diagn Pathol. 2002; 6:56–60.

7. Mostofi FK, Theiss EA, Ashley DJ. Tumors of specialized gonadal stroma in human male patients. Androblastoma, Sertoli cell tumor, granulosa-theca cell tumor of the testis, and gonadal stromal tumor. Cancer. 1959; 12:944–57.

8. Gaylis FD, August C, Yeldandi A, Nemcek A, Garnett J. Granulosa cell tumor of the adult testis: ultrastructural and ultrasonographic characteristics. J Urol. 1989; 141:126–7.

9. Due W, Dieckmann KP, Niedobitek G, Bornhoft G, Loy V, Stein H. Testicular sex cord stromal tumour with granulosa cell differentiation: detection of steroid hormone receptors as a possible basis for tumour development and therapeutic management. J Clin Pathol. 1990; 43:732–7.

10. Al-Bozom IA, El-Faqih SR, Hassan SH, El-Tiraifi AE, Talic RF. Granulosa cell tumor of the adult type: a case report and review of the literature of a very rare testicular tumor. Arch Pathol Lab Med. 2000; 124:1525–8.

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Fig. 1.

Ultrasonography shows a mass with heterogeneous hypoechoic echotexture and multiple variable sized cysts in mass.

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Fig. 2.

The cut surface revealed a huge gray brown to yellow solid tumor that involved almost the whole testis, with multifocal cystic changes and hemorrhages.

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Fig. 3.

The tumor consisted of a homogeneous population of basophilic, bipolar, cells with angular grooved nuclei. Call-Exner bodies imparting a microfollicular pattern were focally present throughout the tumor (x200).

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