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Han, Jeong, and Shim: Additive Expulsion Effect of Tamsulosin after Shock Wave Lithotripsy for Upper Ureteral Stones
Original Article
Korean Journal of Urology

Korean Journal of Urology 2006; 47(8): 813-817.

Published online: 31 August 2006

DOI: https://doi.org/10.4111/kju.2006.47.8.813

Additive Expulsion Effect of Tamsulosin after Shock Wave Lithotripsy for Upper Ureteral Stones

Min Cheol Han, Woo Sik Jeong, Bong Suk Shim

Department of Urology, College of Medicine, Ewha Womans University, Seoul, Korea.

Corresponding author (bonstone@ewha.ac.kr)

Received 3 May 2006       Accepted 13 June 2006

Copyright © 2006 The Korean Urological Association

Abstract

Purpose

We evaluates if the administration of tamsulosin increases the efficacy of extracorporeal shock wave lithotripsy (ESWL) in the patients with upper ureteral stones and if this decreased the use of analgesic drugs after the procedure.

Materials and Methods

A total of 45 patients with stones 6-12mm in size that were located in the upper ureter were enrolled in the study. The patients were randomly divided into two groups. Group 1 (n=23) received 3 times a day oral treatment of 20mg caroverine (a spasmolytic drug). Group 2 (n=22) received one time a day oral therapy of 0.2mg tamsulosin. All the patients received oral treatment for 14 days. Both groups of patients were allowed to use 30mg ketorolac trimethamine intramuscular injections on demand. The endpoint of the study was the stone expulsion rate, the use of analgesics and the drug adverse effects during treatment.

Results

The average stone size was 7.9±2.79mm for group 1 and 8.2±3.14mm for group 2. No statistical difference between the two groups was found for the stone size, age and gender distribution. The expulsion rate was significantly higher in group 2 (90.9%) compared with group 1 (65.2%) (p=0.038). The average number of pain control injections was 0.78 for group 1 and 0.23 for group 2, and there was a statistically significant difference between the two groups (p=0.042).

Conclusions

The use of tamsulosin proved to be effective and safe, as demonstrated by the increased stone expulsion rate and the lesser need for pain control than that when using just a spasmolytic drug for ESWL of upper ureter stones.

Keywords: Urinary calculi, Extracorporeal shockwave lithotripsy, Tamsulosin

Figures and Tables

Fig. 1
Comparison of stone size between the expulsion patients and no-expulsion patients in both groups. No statistically significant difference is found for the stone size (p-values are from chi-square tests).
kju-47-813-g001
Table 1
Patient characteristics at baseline
kju-47-813-i001

*SD: standard deviation

Table 2
Stone-free rate at 2 weeks after extracorporeal shock wave lithotripsy
kju-47-813-i002

*SD: standard deviation

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