Journal List > Korean J Urol > v.47(1) > 1069939

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Moon, Jang, Paik, Lee, Park, Kim, Kim, Choi, Park, Lee, and Woo: Prognostic Significance of E2F3 Expression in Bladder Cancer
Original Article
Korean Journal of Urology

Korean Journal of Urology 2006; 47(1): 75-79.

Published online: 31 January 2006

DOI: https://doi.org/10.4111/kju.2006.47.1.75

Prognostic Significance of E2F3 Expression in Bladder Cancer

Hong Sang Moon, Ki-Seok Jang1, Seung Sam Paik1, Haeng Nam Lee, Sung Yul Park, Gi Young Kim, Sul Il Kim, Hong Yong Choi, Hae Young Park, Tchun Yong Lee, Young Nam Woo

Department of Urology, College of Medicine, Hanyang University, Seoul, Korea.

1Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.

Corresponding author (hychoi1@yahoo.co.kr)

Received 27 September 2005       Accepted 25 October 2005

Copyright © 2006 The Korean Urological Association

Abstract

Purpose

E2F3 is important for cell cycle regulation and DNA replication. Recent studies have reported that members of the E2F family can play specific and diverse roles in the tumorigenesis of human malignancies, and the E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in bladder tumors. We studied the prognostic significance of E2F3 expression in bladder cancer.

Materials and Methods

We examined the expression of E2F3 with using immunohistochemical staining in the tumor samples from 109 patients suffering with bladder cancer, and we analyzed the prognostic significance of E2F3 according to the grade, stage, recurrence and progression of bladder cancer.

Results

We found positive staining for E2F3 in 23 cases (21.1%). The E2F3 expression was correlated with the tumor stage (superficial vs. invasive, p<0.001) and the tumor grade (p=0.001). The E2F3 expression was not correlated with the recurrence and progression of superficial bladder cancer.

Conclusions

In this study, our results showed that the E2F3 expression was observed in a portion of the bladder cancer specimens. These results suggest that E2F3 may contribute to the development of bladder cancer, but it may not play a role as a prognostic factor of bladder cancer.

Keywords: E2F3 transcription factor, Bladder cancer

Figures and Tables

Fig. 1
Immunohistochemical staining for E2F3 in bladder cancer. (A) Diffuse staining for E2F3 in the nucleus of the tumor cells (hematoxylin counterstain, ×400). (B) Negative staining for E2F3 in the nucleus of the tumor cells (hematoxylin counterstain, ×400).
kju-47-75-g001
Table 1
Relationship of the E2F3 expression with superficial and invasive bladder cancer
kju-47-75-i001

p<0.001

Table 2
Relationship of the E2F3 expression with the grade of superficial and invasive bladder cancer
kju-47-75-i002

p=0.001

Table 3
Relationship of the E2F3 expression with recurrence of superficial bladder cancer
kju-47-75-i003

p=0.936

Table 4
Relationship of the E2F3 expression with the progression of recurrent superficial bladder cancer
kju-47-75-i004

p=1.000

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