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Soh, Han, and Yang: The Incidence and Clinicopathologic Predictable Factors for Multifocality in the Patients Who had Radical Nephrectomy Performed for Renal Cell Carcinoma
Original Article
Korean Journal of Urology

Korean Journal of Urology 2006; 47(5): 462-466.

Published online: 31 May 2006

DOI: https://doi.org/10.4111/kju.2006.47.5.462

The Incidence and Clinicopathologic Predictable Factors for Multifocality in the Patients Who had Radical Nephrectomy Performed for Renal Cell Carcinoma

Byung Hyun Soh, Woong Kyu Han, Seung Choul Yang

Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Corresponding author (syang313@yumc.yonsei.ac.kr)

Received 2 December 2005       Accepted 13 April 2006

Copyright © 2006 The Korean Urological Association

Abstract

Purpose

We aimed to assess the influence of the clinical and pathological factors on the multifocality of renal cell carcinoma.

Materials and Methods

We retrospectively reviewed the records of 467 patients (mean age: 54.6 years) who underwent operation for renal cell carcinoma at this hospital between June 1995 and April 2004. We evaluated the pathologic stage, grade, cell type, the histological pattern, tumor necrosis, the tumor size and the features of multifocality. To determine the clinical significant factors related with multifocality in renal cell carcinoma, we used the chi square test and multiple logistic regression analysis.

Results

Of the 467 renal cell carcinomas, 27 cases (5.8%) had multifocal malignant nodules. The average size of the multifocal renal lesions was 17×12×9 mm. The incidence of multifocality was statistically higher in the patients with stage pT3 disease than in those patients with stage pT1 or pT2 disease (p<0.001), and it was also higher for those patients with nuclear grade 3 or 4 than for those patients with nuclear grade 1 and 2 (p=0.005). Only the stage had significant correlation with multifocal disease when performing multiple logistic regression analysis.

Conclusions

Our results suggest that the primary tumor stage is a risk factor for multifocality in the patients with renal cell carcinoma. Therefore, more precise preoperative staging of the primary tumor is required in case of performing nephron sparing surgery.

Keywords: Multifocality, Renal cell carcinoma, Nephrectomy

Figures and Tables

Table 1
The clinicopathologic characteristics of the patients with unifocal renal cell carcinoma and the patients with multifocal renal cell carcinoma and univariate analysis
kju-47-462-i001

*: p<0.05

Table 2
Multivariate analysis of the clinicopathologic factors for multifocality
kju-47-462-i002

*: p<0.05

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