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Lee, Kim, and Shim: The Recurrence of Chronic Pelvic Pain Syndrome and the Role of Uro-Vaxom®
Original Article
Korean Journal of Urology

Korean Journal of Urology 2006; 47(1): 42-46.

Published online: 31 January 2006

DOI: https://doi.org/10.4111/kju.2006.47.1.42

The Recurrence of Chronic Pelvic Pain Syndrome and the Role of Uro-Vaxom®

Ha Na Lee, Jae Sik Kim, Bong Suk Shim

Department of Urology, College of Medicine, Ewha Womans University, Seoul, Korea.

Corresponding author (bonstone@ewha.ac.kr)

Received 7 September 2005       Accepted 8 December 2005

Copyright © 2006 The Korean Urological Association

Abstract

Purpose

Chronic pelvic pain syndrome (CPPS) is the most common urogenital disease in middle aged men, and it shows various symptoms and a high recurrent rate. Uro-Vaxom® is effective for the treatment of urinary tract infection via the activation of the urothelial immune system. The main objectives of this study were to investigate the recurrence of CPPS and to find out if Uro-Vaxom® is helpful to suppress the recurrence of this condition.

Materials and Methods

After completing treatment for CPPS (NIH-IIIa 45, NIH-IIIb 85), 130 patients were given a 12 week course of Uro-Vaxom® 60mg once a day before breakfast. Sixty patients were also included in the study as a control group after they completed the treatment for CPPS (NIH-IIIa 22, NIH-IIIb 38). All of patients were reevaluated 12 weeks and 24 weeks later with the NIH-CPSI criteria and the EPS findings.

Results

The overall recurrent rate for NIH-IIIa disease was 22.7%, and it was 26.3% for the patients with NIH-IIIb disease in the control group, and it was 6.7% for the patients with NIH-IIIa disease and 7.1% for the patients with NIH-IIIb disease in the Uro-Vaxom® group (p<0.05). The classification of the recurrent CPPS was 46.7% NIH-IIIa and 53.3% NIH-IIIb in the control group, and 11.1% NIH-IIIa and 88.9% NIH-IIIb in the Uro-Vaxom® group. The possible predisposing factors related to the recurrence of CPPS were excessive alcoholic drinking (29.2%), overwork (25.0%) and stress (16.7%). In the non-recurrent patients, there was no change of the NIH-Chronic Prostatitis Symptom Index and the EPS findings for all patients during the follow-up period.

Conclusions

There was about a 30% recurrence rate of CPPS within 6 months after treatment, and Uro-Vaxom® may play a significant role to suppress the recurrence of CPPS.

Keywords: Prostatitis, Recurrence, Uro-Vaxom®

Figures and Tables

Fig. 1
NIH-CPSI change between the Uro-Vaxom® group and the control group. There is no significant difference in comparing each components of the NIH-CPSI change between the Uro-Vaxom® group and the control group. However, quality of life in the control group is significantly aggravated with time (p<0.05). NIH-CPSI: National Institutes of Health-Chronic Prostatitis Symtom Index, Statistical analysis: Student's t-test (paired).
kju-47-42-g001
Table 1
Characteristics of patients at baseline, which was the end point of initial treatment
kju-47-42-i001

*: NIH-Chronic Prostatitis Symptom Index, †: white blood cells/high power field (collect first 10ml of voided urine after massage of prostate)

Table 2
Recurrence during the 6 months period after initial treatment (the recurrent rate)
kju-47-42-i002

*IIIa vs IIIb: p>0.05

†Uro-Vaxom® group vs control group : p<0.05

Table 3
Recurrent status according to the classification of chronic pelvic pain syndrome
kju-47-42-i003
Table 4
Possible predisposing factors related to the recurrence
kju-47-42-i004

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