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Abstract
Purpose
This study aimed to evaluate the tumor biologic behavior and prognostic value of inverted papilloma (IP) of the urinary tract.
Materials and Methods
Thirty-one cases (27 males and 4 females, mean age 55.2 years) of urinary IP that were treated at a single center were retrospectively reviewed. There were 21 cases with bladder IP only (group 1), 8 cases with bladder IP and transitional cell carcinoma (TCC) within a single neoplasm (group 2), and 2 cases with IP and TCC in a different location (group 3). The patient and tumor characteristics were analyzed.
Results
There was a male predominance with hematuria being the main presenting symptom in all groups. The most common macroscopic feature of IP was a polypoid lesion in group 1. The most common location of IP was bladder neck (57.1%) in group 1 and lateral bladder wall (75%) in group 2. The most common associated urologic disease was benign prostatic hyperplasia in group 1. Transurethral resection was performed in 30 cases (96.8%). There were no recurrences at a mean follow-up of 19.4 (3-68) months after surgery in 27 cases followed for 3 months or longer.
Conclusions
One-third of urinary IP were associated with TCC within a single neoplasm or in a different location, and this suggests that IP has a malignant potential. However, because there was no recurrence in IP of the urinary tract, a surveillance protocol as frequent as the one suggested for urothelial cancer does not seem to be necessary.
Figures and Tables
References
1. Kunze E, Schauer A, Schmitt M. Histology and histogenesis of two different types of inverted urothelial papillomas. Cancer. 1983. 51:348–358.
2. Asano K, Miki J, Maeda S, Naruoka T, Takahashi H, Oishi Y. Clinical studies on inverted papilloma of the urinary tract: report of 48 cases and review of the literature. J Urol. 2003. 170:1209–1212.
3. Cheng CW, Chan LW, Chan CK, Ng CF, Cheung HY, Chan SY, et al. Is surveillance necessary for inverted papilloma in the urinary bladder and urethra? ANZ J Surg. 2005. 75:213–217.
4. Potts IF, Hirst E. Inverted papilloma of the bladder. J Urol. 1963. 90:175–179.
5. Witjes JA, van Balken MR, van de Kaa CA. The prognostic value of a primary inverted papilloma of the urinary tract. J Urol. 1997. 158:1500–1505.
6. Oh SJ, Lee KS, Lee SE. Inverted papilloma of the bladder: bladder tumor with benign biologic potential. Korean J Urol. 1992. 33:231–238.
7. Kim JH, Lee KH, Doo SW, Choi MS, Lee DH, Moon KH, et al. Inverted papilloma in the prostatic urethra. Korean J Urol. 2006. 47:214–216.
8. Huh JS, Kim DK, Lee CH, Kim JI. Inverted papilloma of the urinary bladder: 3 cases. Korean J Urol. 1996. 37:94–97.
9. Kwak TI, Kim YW, Kim DS, Yoon DK. A case of inverted papilloma of ureter. Korean J Urol. 1997. 38:93–96.
10. Grainger R, Gikas PW, Grossman HB. Urothelial carcinoma occurring within an inverted papilloma of the ureter. J Urol. 1990. 143:802–804.
11. Henderson DW, Allen PW, Bourne AJ. Inverted urinary papilloma: report of five cases and review of the literature. Virchows Arch A Pathol Anat Histol. 1975. 366:177–186.
12. Stein BS, Rosen S, Kendall AR. The association of inverted papilloma and transitional cell carcinoma of the urothelium. J Urol. 1984. 131:751–752.
13. Mattelaer J, Leonard A, Goddeeris P, D'Hoedt M, Van Kerrebroeck P. Inverted papilloma of bladder: clinical significance. Urology. 1988. 32:192–197.
14. Risio M, Coverlizza S, Lasaponara F, Vercesi E, Giaccone G. Inverted urothelial papilloma: a lesion with malignant potential. Eur Urol. 1988. 14:333–338.
15. Spevack L, Herschorn S, Srigley J. Inverted papilloma of the upper urinary tract. J Urol. 1995. 153:1202–1204.
16. Bagley DH, McCue P, Blackstone AS. Inverted papilloma of renal pelvis: flexible ureteroscopic diagnosis and treatment. Urology. 1990. 36:336–338.
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