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Kim, Kim, and Kim: Significance of Erythrocyte Sedimentation Rate and C-reactive Protein as Predictive Factors for Prognosis in Non-metastatic Renal Cell Carcinoma
Original Article
Korean Journal of Urology

Korean Journal of Urology 2006; 47(10): 1059-1064.

Published online: 31 October 2006

DOI: https://doi.org/10.4111/kju.2006.47.10.1059

Significance of Erythrocyte Sedimentation Rate and C-reactive Protein as Predictive Factors for Prognosis in Non-metastatic Renal Cell Carcinoma

Young Kyun Kim, Sun Il Kim, Se Joong Kim

Department of Urology, Ajou University School of Medicine, Suwon, Korea.

Corresponding author (sejoong@ajou.ac.kr)

Received 18 May 2006       Accepted 18 July 2006

Copyright © 2006 The Korean Urological Association

Abstract

Purpose

This study was performed to investigate the significance of preoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and postoperative ESR and CRP nadir as predictive factors for prognosis in patients with non-metastatic renal cell carcinoma (RCC).

Materials and Methods

In 66 patients with non-metastatic RCC for whom ESR and CRP could be measured before radical nephrectomy and during follow-up, the preoperative ESR, preoperative CRP, postoperative ESR nadir and postoperative CRP nadir were compared with the clinicopathological variables.

Results

Patients with elevated preoperative ESR or CRP levels were more likely to have tumors with adverse features, including larger tumor size, higher T stage, higher nuclear grade and more frequent metastasis at follow-up, as compared to those patients with lower preoperative ESR or CRP levels, respectively. Patients with an elevated postoperative CRP nadir developed metastasis more frequently at follow-up as compared to those patients with a lower level of postoperative CRP nadir. The univariate analyses identified tumor size, T stage, preoperative ESR, preoperative CRP and postoperative CRP nadir as significant prognostic factors for recurrence-free survival.

Conclusions

Elevated preoperative ESR, preoperative CRP and postoperative CRP nadir are associated with a worse prognosis and a higher recurrence rate in patients with non-metastatic RCC, suggesting that ESR and CRP are valuable prognostic indicators in RCC.

Keywords: Renal cell carcinoma, Erythrocyte sedimentation rate, C-reactive protein, Prognosis

Figures and Tables

Table 1
Clinicopathological data of 66 patients with renal cell carcinoma
kju-47-1059-i001

ESR: erythrocyte sedimentation rate, CRP: C-reactive protein

Table 2
Relationship between preoperative erythrocyte sedimentation rate (ESR) level and clinicopathological variables
kju-47-1059-i002
Table 3
Relationship between preoperative C-reactive protein (CRP) level and clinicopathological variables
kju-47-1059-i003
Table 4
Univariate and multivariate analysis of recurrence-free survival
kju-47-1059-i004

ESR: erythrocyte sedimentation rate, CRP: C-reactive protein

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