Serous cystadenoma of the pancreas is a benign neoplasm and usually unifocal; multifocal tumors are rare, and to our knowledge, only a few cases have been reported. We describe a case involving two separate serous cystadenomas in the head and body of the pancreas. The patient was a 41-year-old woman with no subjective symptoms. Abdominal ultrasonography performed for the purpose of a routine check-up revealed a septated cystic mass in the body of the pancreas. CBC and blood chemistry revealed no abnormality, but abdominal computed tomography indicated two separate cystic masses with enhanced internal septa in the head and body of the pancreas. Whipple's operation was performed and two serous cystadenomas of the pancreas were diagnosed histopathologically.