A 72-year-old woman was admitted due to a solitary pulmonary nodule incidentally found after routine chestradiography. Chest CT showed a solitary pulmonary nodule without calcification in the right upper lobe. Threeyears earlier, she had spent 3 months in Arizona. Surgical resection was performed after percutaneoustransthoracic fine needle aspiration had suggested malignaney. The lesion was caseous and necrotic, andhisto-logic examination indicated the presence of endosporulating spherules. We report a case ofcoccidioidomyco-sis which was resected in order to rule out lung cancer.