Invasive pulmonary aspergillosis may be a major cause of lethal opportunistic infection in neutropenicpatients. The purpose of this report is to describe a combined treatment modality involving transthoracicinjection of amphotericin B and gelatin solution for persistent mycetoma within the cavity. Mycetoma may interferewith consolidation chemotherapy after intravenous injection of amphotericin B for invasive pulmonary aspergillosisin a patient with acute monocytic leukemia in whom neutropenia developed during remission induction chemotherapy.