A case of primary adenosquamous carcinoma of the liver is reported. A large cystic mass with irregular enhancing wall was seen in the left lobe of the liver; multiple hepatic cysts and metastatic nodules were scattered in both lobes. Sonoguided needle biopsy was performed and on histopathology, adenosquamous carcinoma was diagnosed. The radiologic and pathologic relationships of this unusual neoplasm are discussed.