The retrospective analysis on the clinical utility and side effects of the metrizamide myelography andmetrizamide CT-cisternography were made in 292 patients. Metrizamide CT proved valuable in the diagnosis ofintraspinal neoplasms with total block in myelography, demonstrating the upper margin of the neoplasms in a largenumber(75%) of the cases with neoplasm. Metrizamide study also clearly showed the nature and extent of thesyringomyelia, and arachnoid cyst. Metrizamide CT was also helpful in the diagnosis of spinal stenosis, spinaltrauma and infectious disease of the spine. The most common side effects were transient minor meningealirritations (headache, nausea, vomiting and dizziness)which persisted no more than 48 hours in most of thepatients. Five patients developed major complications such as grand mal seizure, toxic psychosis or asepticmeningits.