Journal List > J Rheum Dis > v.23(2) > 1064306

Lee and Yoo: Effect of Tocilizumab on Serum Hepcidin and Anemia Response in Patients with Rheumatoid Arthritis

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Figure 1.
Hepcidin and anemia of chronic disease. Inflammation increases interleukin-6 production. The increase in hepcidin decreases macrophage iron release, intestinal iron absorption, and iron recycling in the bone marrow. Administering tocilizumab in a patient with rheumatoid arthritis has significant therapeutic implications regarding ameliorating anemia, inflammation, and abnormal iron metabolism.
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